DUTCH Test
Blood testing gives only a momentary snapshot of hormone levels, while urine and saliva together provide a more complete picture of how hormones shift, metabolize, and function throughout the day. The DUTCH Plus® test combines dried urine and saliva samples to track free cortisol and cortisone patterns, cortisol metabolites, and sex hormone metabolism. Urine testing reveals how hormones are being processed and cleared, offering insights into balance, detoxification, and potential overload that blood alone cannot show.
From a holistic perspective, this test is valuable because it highlights patterns rather than isolated numbers. It can uncover signs of HPA axis dysfunction, adrenal fatigue tendencies, estrogen or androgen imbalance, detoxification challenges, and shifts in cortisol metabolism linked to stress, inflammation, gut health, or nutrient depletion. Understanding how hormones ebb, flow, and transform gives us the ability to create personalized nutrition, lifestyle, and stress support strategies that restore balance and resilience.
To request this lab please fill out the form below. Within 24 hours you will receive a formal estimated cost and further instructions.
Details
The DUTCH Plus is a comprehensive dried urine and saliva test that maximizes the available information from sex and adrenal hormone production and metabolism. With easy, at-home sample collection over the course of one day, providers can gain insights into the overall diurnal pattern of free cortisol and cortisone, along with the total distribution of cortisol metabolites. This test offers further insight by including organic acid testing, which evaluates potential nutritional deficiencies, oxidative stress, gut dysbiosis, melatonin levels, and neuroinflammation. With the DUTCH Plus, providers also get a closer look into adrenal function with details about a patient’s cortisol awakening response (CAR) by showing cortisol's natural rise and fall within the first hour of waking.
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3-Hydroxyisovaleric Acid
4-Hydroxyestrone
2-Methoxyestrone
2-Hydroxyestrone
Cortisone Night
Cortisone Evening
Cortisol Evening
Cortisol Night
Cortisol Morning - AM60
Cortisol Morning - AM30
Cortisol Waking
b-Pregnanediol
Cortisone Morning - AM60
Cortisone Morning - AM30
Cortisone Waking
Indican
Creatinine
b-Tetrahydrocortisol
Total Estrogen
Progesterone
Quinolinic Acid
Melatonin
Methylmalonic Acid
Estriol
Estradiol
Estrone
DHEA-S
Metabolized Cortisol
Etiocholanolone
8-Hydroxy-2-deoxyguanosine
16-Hydroxyestrone
Vanillylmandelic Acid
Pyroglutamic Acid
Kynurenic Acid
Homovanillic Acid
5a-Dihydrotestosterone
Xanthurenic Acid
b-Tetrahydrocortisone
a-Tetrahydrocortisol
4-Hydroxyestradiol
2-Hydroxyestradiol
Epi-Testosterone
5b-Androstanediol
5a-Androstanediol
Androsterone
a-Pregnanediol
Testosterone
Estimated days for results: Results should arrive within 10 business days after the lab receives samples.
Test Resources https://education.questdiagnostics.com/faq/FAQ199
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Description via Fullscript.com